
4-night
MSC Cruises
MSC Musica
Nov 12, 2026 · Santos, Sao Paulo, Brazil
→ Other
Your gateway to South American adventures and beyond, with over 100 sailings departing from Brazil's premier cruise port.
CruiseHuddle Snapshot
118
Upcoming Sailings
$229
From
Santos serves as Brazil's primary ocean cruise departure port, located just 80 kilometers from São Paulo's bustling metropolis. This historic port city combines convenient access for millions of South American travelers with a strategic position for exploring both regional coastlines and transatlantic voyages. With 118 upcoming sailings and prices starting at $229, Santos offers an accessible entry point for both first-time cruisers and seasoned ocean travelers.
The port primarily hosts sailings from MSC Cruises and Costa Cruises, with popular ships like MSC Musica, Costa Diadema, and MSC Virtuosa regularly calling Santos home. Most departures explore the stunning Brazilian coastline and neighboring South American ports, though you'll also find Mediterranean-bound voyages for those seeking transatlantic adventures. The terminal facilities are modern and efficient, designed to handle the growing demand for ocean cruising in South America. Getting to Santos is straightforward—São Paulo's Guarulhos International Airport sits about 90 minutes away by car, while Congonhas Airport offers a closer domestic option. Several shuttle services and taxi companies specialize in cruise transfers, making the journey hassle-free.
Santos appeals to a diverse mix of cruisers. Brazilian families appreciate the convenience of departing from their home country without international flights, while international travelers discover an exciting alternative to traditional Caribbean or Mediterranean embarkation points. The port's location means you can explore iconic destinations like Rio de Janeiro, Buenos Aires, and Montevideo, or venture across the Atlantic to Europe. Whether you're drawn to the vibrant culture of South American coastal cities or seeking a unique repositioning cruise, Santos provides the perfect starting point.
Ready to explore your options? Browse the sailings departing from Santos and start planning your next ocean adventure.
Explore Santos' opulent former coffee trading palace with stained-glass ceilings and vintage murals.
Stroll the longest beachfront garden promenade, lined with palms, kiosks and city beaches.
Admire colonial-era architecture and religious art at this centuries-old hilltop monastery.
Hop the vintage trolley through Santos' restored downtown streets and colonial buildings.
Learn about Brazilian soccer legend Pele at his memorial museum near Vila Belmiro.
Wander a lush municipal park showcasing Brazil's native orchids and tropical plants.
Take a guided excursion into Brazil's largest metropolis for shopping, culture and cuisine.
Relax on the golden sands of nearby Guaruja, a popular coastal getaway.
Trace Santos' coffee-export legacy through its port warehouses and historic exchange building.
Cruise past one of Latin America's busiest ports on a scenic harbor excursion.
Ferry to this forested island getaway for waterfalls, beaches and boat rides.
Sample fresh Brazilian seafood dishes at traditional restaurants near the historic center.
Departures
118 total · showing 12

4-night
MSC Cruises
Nov 12, 2026 · Santos, Sao Paulo, Brazil
→ Other

4-night
From $519
MSC Cruises
Nov 16, 2026 · Santos, Sao Paulo, Brazil
→ Other

3-night
From $619
MSC Cruises
Nov 20, 2026 · Santos, Sao Paulo, Brazil
→ Other

2-night
From $547
Costa Cruises
Nov 23, 2026 · Santos, Sao Paulo, Brazil
→ Other

3-night
From $824
Costa Cruises
Nov 23, 2026 · Santos, Sao Paulo, Brazil
→ Other

3-night
From $389
MSC Cruises
Nov 23, 2026 · Santos, Sao Paulo, Brazil
→ Other

4-night
From $519
MSC Cruises
Nov 26, 2026 · Santos, Sao Paulo, Brazil
→ Other

3-night
From $814
Costa Cruises
Nov 26, 2026 · Santos, Sao Paulo, Brazil
→ Other

4-night
From $575
MSC Cruises
Nov 29, 2026 · Santos, Sao Paulo, Brazil
→ Other

4-night
From $927
Costa Cruises
Nov 29, 2026 · Santos, Sao Paulo, Brazil
→ Other

3-night
From $389
MSC Cruises
Nov 30, 2026 · Santos, Sao Paulo, Brazil
→ Other

3-night
From $715
MSC Cruises
Dec 2, 2026 · Santos, Sao Paulo, Brazil
→ Other
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